This study explores the multilayered constraints and negotiation processes experienced by women with disabilities in Lao PDR (Laos). A qualitative case study approach was adopted, involving in-depth interviews with eight women actively engaged in sport. Drawing on the Hierarchical Model of Leisure Constraints (HMLC) and an intersectional perspective, the analysis examines how constraints on sport participation are shaped by the interaction of gender, disability, socioeconomic conditions, and place of residence. The findings reveal key intrapersonal, interpersonal, and structural constraints, including low self-efficacy, limited access to education and transport, restrictive family expectations, and stigma within the community. Despite these challenges, participants negotiated constraints through relocation to urban areas, the development of peer networks, engagement with disability support organizations, participation in sport competitions, and the maintenance of employment. These processes enabled participants to sustain sport participation and to gain greater recognition and support from their families and communities. By demonstrating how intersecting inequalities shape both constraints and negotiation processes in a Global South context, this study contributes to research on disability sport participation and highlights the value of intersectionality for understanding diverse experiences of sport participation.