The burgeoning field of sport-for-development (SFD) is witnessing a steady increase in experience-related empirical investigations. To support academics—and in particular young and emerging scholars—with a rigorous framework for investigating social and cultural phenomena in different SFD contexts, we propose the process-oriented sport in development settings (SPIDS) research framework. SPIDS represents a guiding framework that advocates a qualitative approach to researching SFD projects in which multiple methods are combined for a holistic in-depth investigation. In this paper, we apply practical examples from the SFD field to the SPIDS framework and discuss its individual sections in a step-by-step manner. Specific focus is placed on aspects of reflection and reflexivity as distinctly important and underpinning aspects of qualitative SFD research.